Computerized Tomographic Colonography: Performance Evaluation in a Multicenter Setting

Protocol Documents

Summary Protocol [PDF]

Principal Investigator: C. Daniel Johnson, MD

Status:  Primary Aim Paper Published (The citation can be found on the publications table by clicking on the link to the left.)

Main Objective: To evaluate the accuracy of CTC compared with pathology and colonoscopy for detecting clinically important colorectal neoplasia (defined as lesions with diameter at least 1 cm).

Participants: This retrospective study used computerized tomographic colonography (CTC) images and colonoscopy results collected from participants examined at multiple institutions throughout the United States.

Study Design Summary: Eighteen radiologists participated as readers in this study, each interpreting images on two different workstations (one reading group on one workstation, and a second reading group on the other workstation). A counterbalanced design was employed such that each participant's CTC images were to be interpreted by 4 radiologists on each of the three workstations, for a total of 12 interpretations.