A major objective of NLST-ACRIN is the creation of a national resource of biospecimens consisting of serial collections of blood components (plasma and buffy coat), urine, and sputum from a subset of participants at each of the three annual NLST screening exams as well as resected tissues from trial participants with lung cancer. 

By coupling biospecimen collection with imaging-based screening, the NLST-ACRIN Biorepository is relatively enriched for early clinical stage lung cancers and associated biospecimens, and should provide a unique resource of extremely well characterized biospecimens with longitudinal data.  The NLST-ACRIN Biorepository is available for all research platforms that will validate biomarkers of early lung cancer that are proven to have potential in preliminary testing.   

NLST-ACRIN Biospecimen Research Opportunity [PDF]

ACRIN Data Sharing Policy and Biorepository Process

The NLST-ACRIN Biorepository is governed by the ACRIN Data Sharing Policy, which outlines ACRIN's data sharing process and summarizes what information ACRIN will release to requesters.

NLST-ACRIN Biorepository Application Review Process [PPT]

Data Sharing Policy 

Data Sharing Policy [DOC]

Requests Forms for NLST-ACRIN Biospecimens, Images and Clinical Data

Individuals interested in obtaining ACRIN-NLST biospecimens, images and/or clinical data for projects unrelated to ACRIN-NLST study aims described in the protocol ( should review the Biorepository Summary and complete the following form. 

Application for NLST-ACRIN Biospecimens [DOC]

PLEASE NOTE: The NLST biorepository was relocated in March 2017. Applications received for the April 2017 and August 2017 review cycles will be reviewed, but specimen processing for approved applications will be delayed while inventory is processed and confirmed during the transition period. Please anticipate an extended period of time to fulfill specimen requests if your application is approved.


Submission Deadlines

Applications will be accepted November 1, April 1, and August 1. 

Applications will be accepted November 1, April 1, and August 1.