PROTOCOL SUMMARY TABLE

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PROTOCOL	DESCRIPTION	MODALITY	STATUS	ACCRUAL
Scientific Collaborator				Actual Accrual Accrual Goal
Abdominal Protocols
4002	Metastatic Colorectal Cancer: Treatment Response with Dynamic Contrast MRI Mark Rosen, MD, PhD Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions	Magnetic Resonance Imaging	In Follow-up	6 60
6656	Colon Cancer: Diagnostic Accuracy of CT Colonography C. Daniel Johnson, MD	Computed Tomography	Results Published	117 117
6659	Prostate Cancer: Staging with MRI and MRS Jeffrey C. Weinreb, MD	Magnetic Resonance Imaging	Results Published	134 134
6664	Colorectal Cancer: Screening with CT Colonography C. Daniel Johnson, MD	Computed Tomography	Results Published	2617 2600
6665 RTOG	Malignant GI Stromal Tumors: Treatment Monitoring with PET Burton Eisenberg, MD RTOG Study Chair Annick Van den Abbeele, MD ACRIN Principal Investigator	Positron Emission Tomography	In Analysis	63 63
6673	Liver Cancer: Treatment with RF Ablation Gerald Dodd, III, MD	Radiofrequency Ablation	In Analysis	51 40
6687 DoD	18F-Fluoride PET as a Biomarker for Prostate Cancer and Bone Metastases Evan Y. Yu, MD Note: ARRA funding supports this trial.	Positron Emission Tomography	Closed	18 24
6690	Comparison of Multiphase Contrast-Enhanced CT and MRI for Diagnosis of HCC and Liver Transplant Allocation Christoph Wald, MD, PhD Note: The trial is endorsed by the United Network of Organ Sharing	Computed Tomography	Open	76 440
6701 RSNA/QIBA	Repeatability Assessment of Quantitative DCE-MRI and DWI: A Multicenter Study of Functional Imaging Standardization in the Prostate Mark A. Rosen, MD, PhD	Magnetic Resonance Imaging	Soon to Open	30
7151	Extracolonic Findings: a Sub-study of the National CT Colonography Trial (ACRIN 6664) Hanna Zafar, MD, MHS Note: This trial is funded by the ACRIN Fund for Imaging Innovation	Computed Tomography	Open	0
Breast Protocols
4006	Comparison of Full-Field Digital Mammography with Digital Breast Tomosynthesis in Screening Call-Back Rate Emily F. Conant, MD Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions	Mammography	Accrual Complete	558 550
6652	Breast Cancer: Screening with Digital Mammography Etta Pisano, MD	Mammography	Results Published	49529 49520
6657 CALGB	Breast Cancer: Treatment Monitoring with Dynamic MRI Nola M. Hylton, PhD ACRIN Principal Investigator Laura J. Esserman, MD, MBA CALGB Study Chair	Magnetic Resonance Imaging	In Analysis	356 377
6666	Breast Cancer: Screening with Ultrasound Wendie A. Berg, MD, PhD	Ultrasound	In Analysis	2809 2809
6667	Breast Cancer: Screening of Contralateral Breast with MRI Constance Lehman, MD, PhD	Magnetic Resonance Imaging	Results Published	1007 1007
6683	Computer Aided Detection and Digital Mammography Etta D. Pisano, MD	Computed Tomography	In Analysis	N/A
6688 VCU	Phase II Study of FLT PET in Invasive Breast Cancer Paul R. Jolles, MD, VCU Study Chair ACRIN Co-Investigators David Mankoff, MD, PhD Lale Kostakoglu, MD, MPH Note: ARRA funding supports this trial.	Positron Emission Tomography	Open	84 54
6691	Monitoring and Predicting Breast Cancer Neoadjuvant Chemotherapy Response Using Diffuse Optical Spectroscopic Imaging (DOSI) Bruce J. Tromberg, PhD Note: ARRA funding supports this trial.	Diffuse Optical Spectroscopic Imaging	Open	20 60
6698	Diffusion-weighted MRI Biomarkers for Assessment of Breast Cancer Response to Neoadjuvant Treatment: An I-SPY 2 Trial Substudy ACRIN Principal Investigator Nola Hylton, PhD	Magnetic Resonance Imaging	Soon to Open	304
Cardiovascular Protocols
4005	CT Coronary Angiogram vs Traditional Care for Low-Risk ED Pts with Potential Acute Coronary Syndromes Study Co-Chairs: Harold Litt, MD, PhD Judd Hollander, MD Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions	Computed Tomography	In Follow-up	1393 1365
4008	Assessment of Left Ventricular Hypertrophy and Fibrosis with Cardiac MRI After Aortic Valve Replacement Study Co-chairs: Scott Akers, MD, PhD Julio A. Chirinos, MD Philadelphia Veterans Administration Medical Center	Magnetic Resonance Imaging	Soon to Open	80
4701	RESCUE: Randomized Evaluation of Patients with Stable Angina Comparing Utilization of Diagnostic Examinations Arthur Stillman, MD, PhD Note: Funded by the Agency for Healthcare Research and Quality	Computed Tomography	Open	454 4300
Gynecological Protocols
6651 GOG	Cervical Cancer: Staging with CT and MRI Hedvig Hricak, MD, PhD	Magnetic Resonance Imaging	Results Published	208 208
6671 GOG	Cervical and Endometrial Cancers: Staging with PET/CT Mostafa Atri, MD ACRIN Principal Investigator Michael Gold, MD GOG Principal Investigator	Positron Emission Tomography	Open	258 380
6682	Cervical Cancer: 64Cu-ATSM PET/CT Assessment of Tumor Hypoxia Farrokh Dehdashti, MD	Positron Emission Tomography	Open	38 100
6695 GOG	Ovarian Cancer: Evaluating Perfusion CT as Prognostic Indicator – a sub-study of GOG 0262 ACRIN 6695 Co-Principal Investigators Chaan Ng, MD Ting Yim Lee, PhD ACRIN 6695 GOG Co-investigator Robert Coleman, MD	Computed Tomography	Open	8 78
Head/Neck/Neuro Protocols
6658	Supraglottic Cancer: Volume Measurement Reliability with CT Suresh Mukherji, MD	Computed Tomography	Results Published	24 24
6662 NABTT	Malignant Glioma: Volume Measurement Reliability with MRI Birgit B. Ertl-Wagner, MD	Magnetic Resonance Imaging	Results Published	48 48
6677 RTOG	Recurrent Glioblastoma: Substudy Tumor Staging with MR Perfusion Imaging and MR Spectroscopy A. Gregory Sorensen, MD ACRIN Principal Investigator Mark Gilbert, MD RTOG Study Chair	Magnetic Resonance Imaging	In Analysis	123 121
6684	Newly Diagnosed Glioblastoma: Assessment of Tumor Hypoxia with FMISO PET, DCE MRI and MRS Elizabeth R. Gerstner, MD David Mankoff, MD, PhD Note: ARRA funding through an ACTNOW grant supports this trial.	Positron Emission Tomography	Open	34 50
6685	Staging of Head and Neck Cancer: Assessment of FDG-PET/CT and the Impact on N0 Neck Surgical Treatment Val J. Lowe, MD, Brendan C. Stack, Jr., MD, FACS	Positron Emission Tomography	Open	102 292
6686 RTOG	Newly Diagnosed Glioblastoma: Substudy of Tumor Assessment with Advanced MRI Jerold Boxerman, MD ACRIN Principal Investigator Mark Gilbert, MD RTOG Study Chair	Magnetic Resonance Imaging	Accrual Complete	60 264
6689 RTOG	Newly Diagnosed Glioblastoma: Substudy of Tumor Assessment with FLT PET and DCE MRI and MRS	Magnetic Resonance Imaging	Closed	2 51
Neuroscience Protocols
4003	Evaluation of a Novel PET Radiopharmaceutical to Identify Patients with Alzheimer’s Disease Steven E. Arnold, MD Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions	Positron Emission Tomography	In Analysis	32 30
4004	Evaluation of a Novel PET Radiopharmaceutical to Identify Patients with Alzheimer’s Disease James Mountz, MD, PhD Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions	Positron Emission Tomography	In Analysis	24 30
Other Protocols
2410	Response-Adapted Therapy Based on PET for Bulky Stage I and II Hodgkin’s Lymphoma Study Principal Investigator Ranjana Advani, MD ACRIN Co-PIs Lale Kostakoglu, MD, MPH Barry Siegel, MD	Positron Emission Tomography	Open	0
4001	Knee Articular Cartilage Damage in Osteoarthritis: MRI Image Markers Timothy J. Mosher, MD Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions	Magnetic Resonance Imaging	Results Published	53 54
6660	Pediatric Malignancy: Staging with Whole-Body MRI Marilyn Siegel, MD	Magnetic Resonance Imaging	In Analysis	192 184
6661	Radiofrequency Ablation of Bone Metastases Using CT Guidance Damian E. Dupuy, MD	Radiofrequency Ablation	Results Published	66 75
6680 SWOG	ACRIN SPECT Component of the SWOG S0518 Carcinoid Treatment Trial Lale Kostakoglu, MD ACRIN Investigator	SPECT	In Follow-up	97 NA
Thoracic Protocols
4703 DoD	DECAMP Study 1: Diagnosis and Surveillance of Indeterminate Pulmonary Nodules Co-Principal Investigators Avrum Spira, MD, MSc Mitchell Schnall, MD, PhD	Computed Tomography	Soon to Open	500
6654 NCI LSS	National Lung Screening Trial Denise Aberle, MD	Computed Tomography	Results Published	18894 25000
6668 RTOG	Lung Cancer: FDG-PET Assessment for Stage III Non-Small Cell Lung Cancer Mitchell Machtay, MD	Computed Tomography	In Follow-up	251 250
6678	Lung Cancer: Evaluation of Treatment Response with PET Wolfgang Weber, MD	Positron Emission Tomography	In Follow-up	96 228
6697 RTOG	Treatment Monitoring: Adaptive Radiotherapy Using During-treatment FDG-PET for NSCLC Feng-Ming Kong, MD, PhD RTOG Principal Investigator, Daniel Pryma, MD ACRIN Principal Investigator	Positron Emission Tomography	Open	58