Role of Radiology in the Pretreatment Evaluation of Invasive Cervical Cancer
Protocol Documents
Summary Protocol [PDF]
Principal Investigator: Hedvig Hricak, MD, PhD
Status: Primary- and Secondary-Aim Papers Published
Main Objective: To compare the diagnostic performance of computed tomography (CT) and magnetic resonance imaging (MRI) to each other and to clinical FIGO staging in the primary evaluation of invasive cancer of the cervix.
Participants: Women with biopsy-documented invasive cervical cancer who are planning to have surgery.
Study Design Summary: Participants will undergo both CT and MRI before surgery. The first imaging study will take place within 20 days of registration. Scheduled surgery will follow the first imaging study within 6 weeks. CT and MR images will be collected and reviewed for image quality. A reader study will assess variability across radiologists. Participant questionnaires will be administered one week after last imaging to assess quality of life. A health utilities will be administered at one and 12 months after surgery. Follow-up information will be collected on each participant for a 2-year period.