PROTOCOLS
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PROTOCOL DESCRIPTION MODALITY STATUS ACCRUAL
Scientific
Collaborator
      Actual Accrual
Accrual Goal
Abdominal Protocols
4002 Metastatic Colorectal Cancer: Treatment Response with Dynamic Contrast MRI
Mark Rosen, MD, PhD

Note: Funded by the PA Department of Health and carried out by ACRIN PA network institutions
Magnetic Resonance Imaging Closed 6
60
 
6656 Colon Cancer:
Diagnostic Accuracy of CT Colonography
C. Daniel Johnson, MD
Computed Tomography Results Published 117
117
 
6659 Prostate Cancer:
Staging with MRI and MRS
Jeffrey C. Weinreb, MD
Magnetic Resonance Imaging Results Published 134
134
 
6664 Colorectal Cancer:
Screening with CT Colonography
C. Daniel Johnson, MD
Computed Tomography Results Published 2617
2600
 
6665
RTOG
Malignant GI Stromal Tumors: Treatment Monitoring with PET
Burton Eisenberg, MD
RTOG Study Chair
Annick Van den Abbeele, MD
ACRIN Principal Investigator
Positron Emission Tomography Results Published 63
63
 
6673 Liver Cancer:
Treatment with RF Ablation
Gerald Dodd, III, MD
Radiofrequency Ablation In Analysis 51
40
 
6687
DoD
18F-Fluoride PET as a Biomarker for Prostate Cancer and Bone Metastases
Evan Y. Yu, MD

Note: ARRA funding supports this trial.
Positron Emission Tomography In Analysis 18
24
 
6690 Comparison of Multiphase Contrast-Enhanced CT and MRI for Diagnosis of HCC and Liver Transplant Allocation
Christoph Wald, MD, PhD
Note: The trial is endorsed by the United Network of Organ Sharing
Computed Tomography Open 211
440
 
6701
RSNA/QIBA
Repeatability Assessment of Quantitative DCE-MRI and DWI: A Multicenter Study of Functional Imaging Standardization in the Prostate
Mark A. Rosen, MD, PhD
Magnetic Resonance Imaging Open 4
30
 
7151 Extracolonic Findings: a Sub-study of the National CT Colonography Trial (ACRIN 6664)
Hanna Zafar, MD, MHS
Note: This trial is funded by the ACRIN Fund for Imaging Innovation
Computed Tomography Open
NA
 
Breast Protocols
4006 Comparison of Full-Field Digital Mammography with Digital Breast Tomosynthesis in Screening Call-Back Rate
Emily F. Conant, MD

Note: Funded by the PA Department of Health and carried out by ACRIN PA network institutions
Mammography Accrual Complete 558
550
 
6652 Breast Cancer:
Screening with Digital Mammography
Etta Pisano, MD
Mammography Results Published 49529
49520
 
6657
CALGB
Breast Cancer:
Treatment Monitoring with Dynamic MRI
Nola M. Hylton, PhD
ACRIN Principal Investigator
Laura J. Esserman, MD, MBA
CALGB Study Chair
Magnetic Resonance Imaging In Analysis 356
377
 
6666 Breast Cancer:
Screening with Ultrasound
Wendie A. Berg, MD, PhD
Ultrasound Results Published 2809
2809
 
6667 Breast Cancer:
Screening of Contralateral Breast with MRI
Constance Lehman, MD, PhD
Magnetic Resonance Imaging Results Published 1007
1007
 
6683 Computer Aided Detection and Digital Mammography
Etta D. Pisano, MD
Computed Tomography In Analysis
N/A
 
6688
VCU
Phase II Study of FLT PET in Invasive Breast Cancer
Paul R. Jolles, MD, VCU Study Chair
ACRIN Co-Investigators
David Mankoff, MD, PhD
Lale Kostakoglu, MD, MPH

Note: ARRA funding supports this trial.
Positron Emission Tomography In Analysis 90
54
 
6691 Monitoring and Predicting Breast Cancer Neoadjuvant Chemotherapy Response Using Diffuse Optical Spectroscopic Imaging (DOSI)
Bruce J. Tromberg, PhD
Note: ARRA funding supports this trial.
Diffuse Optical Spectroscopic Imaging In Follow-up 60
60
 
6694
Alliance
Effect of Preoperative Breast MRI on Surgical Outcomes, Costs and Quality of Life
ACRIN Principal Investigator
Christopher Comstock, MD
Alliance Principal Investigator
Isabelle Bedrosian, MD
Magnetic Resonance Imaging Open
488
 
6698 Diffusion-weighted MRI Biomarkers for Assessment of Breast Cancer Response to Neoadjuvant Treatment: An I-SPY 2 Trial Substudy
ACRIN Principal Investigator
Nola Hylton, PhD
Magnetic Resonance Imaging Open 257
304
 
6702 Diffusion Weighted Imaging for Detection and Diagnosis of Breast Cancer
Savannah Partridge, PhD
Magnetic Resonance Imaging Open
100
 
Cardiovascular Protocols
4005 CT Coronary Angiogram vs Traditional Care for Low-Risk ED Pts with Potential Acute Coronary Syndromes
Study Co-Principal Investigators:
Harold Litt, MD, PhD
Judd Hollander, MD

Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions
Computed Tomography Results Published 1393
1365
 
4008 Assessment of Left Ventricular Hypertrophy and Fibrosis with Cardiac MRI After Aortic Valve Replacement
Co-Principal Investigators:
Scott Akers, MD, PhD
Julio A. Chirinos, MD
Magnetic Resonance Imaging Open 15
80
 
4701 RESCUE: Randomized Evaluation of Patients with Stable Angina Comparing Utilization of Diagnostic Examinations
Arthur Stillman, MD, PhD

Note: Funded by the Agency for Healthcare Research and Quality
Computed Tomography In Follow-up 1050
4300
 
Gynecological Protocols
6651
GOG
Cervical Cancer:
Staging with CT and MRI
Hedvig Hricak, MD, PhD
Magnetic Resonance Imaging Results Published 208
208
 
6671
GOG
Cervical and Endometrial Cancers:
Staging with PET/CT
Mostafa Atri, MD
ACRIN Principal Investigator
Michael Gold, MD
GOG Principal Investigator
Positron Emission Tomography In Analysis 384
380
 
6682 Cervical Cancer:
64Cu-ATSM PET/CT Assessment of Tumor Hypoxia
Farrokh Dehdashti, MD
Positron Emission Tomography In Follow-up 73
100
 
6695
GOG
Ovarian Cancer: Evaluating Perfusion CT as Prognostic Indicator – a sub-study of GOG 0262
ACRIN 6695 Co-Principal Investigators
Chaan Ng, MD
Ting Yim Lee, PhD
ACRIN 6695 GOG Co-investigator
Robert Coleman, MD
Computed Tomography In Analysis 120
78
 
Head/Neck/Neuro Protocols
6658 Supraglottic Cancer:
Volume Measurement Reliability with CT
Suresh Mukherji, MD
Computed Tomography Results Published 24
24
 
6662
NABTT
Malignant Glioma:
Volume Measurement Reliability with MRI
Birgit B. Ertl-Wagner, MD
Magnetic Resonance Imaging Results Published 48
48
 
6677
RTOG
Recurrent Glioblastoma:
Substudy Tumor Staging with MR Perfusion Imaging and MR Spectroscopy
Jerrold Boxerman, MD, PhD
ACRIN Principal Investigator
Mark Gilbert, MD
RTOG Study Chair
Magnetic Resonance Imaging In Analysis 123
121
 
6684 Newly Diagnosed Glioblastoma: Assessment of Tumor Hypoxia with FMISO PET, DCE MRI and MRS
Elizabeth R. Gerstner, MD
David Mankoff, MD, PhD
Note: ARRA funding through an ACTNOW grant supports this trial.
Positron Emission Tomography Closed 50
50
 
6685 Staging of Head and Neck Cancer: Assessment of FDG-PET/CT and the Impact on N0 Neck Surgical Treatment
Val J. Lowe, MD,
Brendan C. Stack, Jr., MD, FACS
Positron Emission Tomography Open 216
292
 
6686
RTOG
Newly Diagnosed Glioblastoma: Substudy of Tumor Assessment with Advanced MRI
Jerrold Boxerman, MD, PhD
ACRIN Principal Investigator
Mark Gilbert, MD
RTOG Study Chair
Magnetic Resonance Imaging In Analysis 60
264
 
6689
RTOG
Newly Diagnosed Glioblastoma: Substudy of Tumor Assessment with FLT PET and DCE MRI and MRS
Magnetic Resonance Imaging Closed 2
51
 
Lymphoma Protocols
2410 Response-Adapted Therapy Based on PET for Bulky Stage I and II Hodgkin’s Lymphoma
Study Principal Investigator Ranjana Advani, MD ACRIN Co-PIs Lale Kostakoglu, MD Barry Siegel, MD
Positron Emission Tomography Closed N/A
0
 
Neuroscience Protocols
4003 Evaluation of a Novel PET Radiopharmaceutical to Identify Patients with Alzheimer’s Disease
Steven E. Arnold, MD

Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions
Positron Emission Tomography Results Published 32
30
 
4004 Evaluation of a Novel PET Radiopharmaceutical to Identify Patients with Alzheimer’s Disease
James Mountz, MD, PhD

Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions
Positron Emission Tomography In Analysis 24
30
 
Other Protocols
4001 Knee Articular Cartilage Damage in Osteoarthritis: MRI Image Markers
Timothy J. Mosher, MD

Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions
Magnetic Resonance Imaging Results Published 53
54
 
4007 Pennsylvania Quality Initiative for CT Radiation Dose Reduction
Harold Litt, MD, PhD

Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions
Computed Tomography Open
NA
 
6660 Pediatric Malignancy:
Staging with Whole-Body MRI
Marilyn Siegel, MD
Magnetic Resonance Imaging Results Published 192
184
 
6661 Radiofrequency Ablation of Bone Metastases Using CT Guidance
Damian E. Dupuy, MD
Radiofrequency Ablation Results Published 66
75
 
6680
SWOG
ACRIN SPECT Component of the
SWOG S0518 Carcinoid Treatment Trial
Lale Kostakoglu, MD
ACRIN Investigator
SPECT In Follow-up 110
NA
 
Thoracic Protocols
4703
DoD
DECAMP Study 1: Diagnosis and Surveillance of Indeterminate Pulmonary Nodules
Co-Principal Investigators
Avrum Spira, MD, MSc
Mitchell Schnall, MD, PhD
Computed Tomography Open 116
500
 
4704
DoD
DECAMP Study 2: Screening of Indeterminate Pulmonary Nodules
Co-Principal Investigators Avrum Spira, MD, MSc Mitchell Schnall, MD, PhD
Computed Tomography Open 44
880
 
6654
NCI LSS
National Lung Screening Trial
Denise Aberle, MD
Computed Tomography Results Published 18894
25000
 
6668
RTOG
Lung Cancer: FDG-PET Assessment for Stage III Non-Small Cell Lung Cancer
Mitchell Machtay, MD
Computed Tomography In Analysis 251
250
 
6678 Lung Cancer:
Evaluation of Treatment Response with PET
Wolfgang Weber, MD
Positron Emission Tomography In Analysis 96
228
 
6697
RTOG
Treatment Monitoring: Adaptive Radiotherapy Using During-treatment FDG-PET for NSCLC
Feng-Ming Kong, MD, PhD
RTOG Principal Investigator,
Daniel Pryma, MD
ACRIN Principal Investigator
Positron Emission Tomography Open 45
138